Cholesteryl Ester Transfer Protein (CETP) is an important protein in lipid metabolism. It facilitates the transport of cholesterol from high-density lipoproteins (HDLs) to triglyceride-rich lipoproteins and low-density lipoproteins (LDLs) in exchange for triglycerides. Pharmacological and genetic inhibition of CETP leads to a high level of cholesterol in HDL-particles and a low level of cholesterol in triglyceride-rich lipoproteins, LDLs, and lipoprotein(a) leading to a favorable lipid profile. The largest randomized clinical trial of a drug that inhibits CETP has shown an effect on reduction of risk of cardiovascular disease. Genetic studies have found that inhibition of CETP associated with a lower risk of cardiovascular disease but possibly also with a higher risk of age-related macular degeneration.
Det här är ett utplock av en intressant artikel från KBN – Nr. 1 – vol. 35 – 2023.